Evaluation of Interleukin 2, Interleukin 10, and Interferon Gamma Among Pregnant Women Co-infected With HIV and Plasmodium falciparum

Background: In pregnancy, the body undergoes modulation of pro-inflammation responses to ensure fetal survival, and these adjustments may decrease maternal immune defenses promote infections. Objectives: This study was conducted determine interleukin 2 (IL-2), IL-10, interferon gamma (IFN-γ) among pregnant women co-infected with HIV Plasmodium falciparum in Edo State, Nigeria. Methods: at Central Hospital, Benin City, State. A total 200 participants were enrolled, consisting 150 P. 50 non-pregnant (as controls) who neither infected nor falciparum. Venous blood specimen collected for detection, CD4 T-lymphocyte estimation, IL-2, IFN-γ assays using standard methods. Results: Among HIV-infected women, IL-2 (P = 0.0070), IL-10 0.0179) 0.1564) values lower primiparous compared multiparous women. married had significantly higher 0.0085) levels 0.0332) single while marital status did not affect level HIV. Only increased 0.0012) increasing trimester. The tested cytokine those malaria without Conclusions: infection affects malaria.